• Basic Information
• Additional Info

Basic Information

• Project No. and Title: NE1201 : Mycobacterial Diseases of Animals
• Period Covered: 12/01/2013 to 12/31/2015
• Date of Report: 07/15/2016
• Annual Meeting Dates: 10/18/2014 to 10/18/2014

Participants

Included on the meeting minutes.

Accomplishments

Impacts

1. Establishment of a powerful tool for elucidating basic principles about M bovis transmission dynamics, interpreted at the appropriate epidemiological scale.
2. Discovery of TiKa supplements will, which helps stimulate growth of MTB, M. bovis and MAP, promotes sigH and early re-aeration responses, limits lag phase, delays stationary phase, increases division rate of slow growing mycobacteria at least 2 fold, and finally decrease time to visible colony formation.
3. Establishment of a new program that uses common Unix programs to output easy to interpret SNP comparisons from multiple VCFs as both SNP tables and fasta files to generate phylogenetic trees for mycobacterial cultures, using reference based and reference independent criteria.
4. Conduction of a survey among producers asking for feedback regarding knowledge and information on JD and bTB, and setting criteria for the next steps based on the results among milk and beef farmers.
5. Establishing an international relationship with Italy, and creation of a convenient risk assessment tool, provide education as needed “just-in-time”, simplify the management and testing plan, make it easy to collect data, and establish accountability, and development of a website http://iramp.izsler.it/.
6. The Development of in vitro model systems to address important pathogenic mechanisms of MAP associated with the survival in ruminants
7. Evaluation of results from a study performed for the Bovine Tuberculosis In Enzootic/Endemic Regions of Egypt.
8. Discovery of a functional variant in the promoter region of EDN2 associated with map tissue infection up-regulates EDN2 expression
9. Selection for Heritable Resistance to Control Johne’s Disease in Farmed Deer
10. Development of Programs to develop and evaluate new generations of vaccines for bovine TB
11. Development of a recombinant multi-stage DIVA vaccine against Johne’s disease

Publications