NC1039: N-3 polyunsaturated fatty acids and human health and disease

(Multistate Research Project)

Status: Inactive/Terminating

SAES-422 Reports

11/11/1111

12/17/2008

01/07/2010

Broughton KS, Hahn B, Ross E. Docosahexaenoic acid and eicosapentaenoic acid differently affect ovarian prostaglandin levels in rats. Nutrition Research 2009;29:510-518.

Broughton KS, Rule DC, Ye Y, Zhang X,Driscoll M, Culver B. Dietary omega-3 fatty acids differentially influence ova release and ovarian COX-1 and COX-2 expression in rats. Nutrition Research 2009;29:197-205.


Whelan, J., Jahns, L. and Kavanagh-Prochaska, K. DHA: Measurements in Food and Dietary Exposure. Prostaglandins Leukot Essent Fatty Acids. 2009;81:133-136.

Harris, W.S., Lefevre, M., Dariush Mozaffarian, D., Toner, C., Colombo, J., Cunnane, S., Holden, J.M., Klurfeld, D.M., Morris, M.C. and Whelan, J. Towards Establishing Dietary Reference Intakes for Long Chain Omega-3 Fatty Acids. J. Nutr. 2009;139: 804S-819S.

Liu LF, Koba K, Purushotham A, Wendel AA, Lee K, DeIuliis J, Belury MA. Regulation of adipose triglyceride lipase by rosiglitazone. Diab Obes Metab, 11(2):131-142, 2009 (ISI 2.434)

Malinauskas, B. & Heidal, K. 2009. The relationship between physical activity, omega-3 fatty acids, and cardiovascular disease risk factors in college. Southeast Chapter of the American College of Sports Medicine.

Sapiro JM, Mashek MT, Greenberg AS, Mashek DG. 2009 Hepatic triacylglycerol hydrolysis activates PPAR-±. Journal of Lipid Research 2009;50(8):1621-1629.

Whelan, J. Dietary Stearidonic Acid is a Long Chain Omega-3 Polyunsaturated Fatty Acid with Potential Health Benefits. J. Nutr. 2009;139: 510.

Whelan, J., Jahns, L. and Kavanagh-Prochaska, K. DHA: Measurements in Food and Dietary Exposure. Prostaglandins Leukot Essent Fatty Acids. 2009;81:133-136.

Wortman, P., Miyazaki, Y., Kalupahana, N.S., Kim, S., Fletcher, S., Hansen-Petrik, M., Saxton, A., Claycombe, K.J., Voy, B.H., Whelan, J. and Moustaid-Moussa, N. Polyunsaturated Fatty Acids Modulate Prostaglandin E2 Secretion and Markers of Lipogenesis in Adipocytes. Nutr Metab 2009;21:5-27.

Dvorak NJ, Riley RT, Harris M and McGregor JA. Fumonisin mycotoxin contamination of corn-based foods consumed by potentially pregnant women in Southern California. J Reprod Medicine 2008;53:672-676.

Hansen, R.A., Harris, M.A., Pluhar, G.E., Motta, T., Brevard, S., Ogilvie, G.K., Fettman, M.J. and Allen, K.G.D. Fish oil decreases matrix metalloproteinases in knee synovia of dogs with inflammatory joint disease. J. Nutr. Biochem., 2008;19:101-108.

McDaniel JC, Belury M, Ahijevych K, Blakely W. Omega-3 fatty acids effect on wound healing. Wound Repair and Regeneration 2008;16:337-345 (ISI 1.700)

McEntee, M.F., Ziegler, C.C., Reel, D.,Tomer, K., Shoieb, A., Ray, M., Li, X., Nielsen, N., O'Rourke, D. and Whelan, J. Dietary Polyunsaturated Fatty Acids Modulate the Response of Androgen-Dependent Prostate Cancer to Hormone Ablation and Progression to Androgen-Independent Growth. Am J Pathol. 2008;173:229-41.

Whelan, J. Health Implications of Changing Linoleic Acid Intakes. Prostaglandins Leukot Essent Fatty Acids 2008;79:165-167.

Whelan, J. (n-6) and (n-3) Polyunsaturated Fatty Acids and the Aging Brain: Food for Thought. J. Nutr. 2008:138: 2521-2522.

12/17/2010

Broughton KS, Bayes J, Culver B. High ±-linolenic acid and fish oil ingestion promotes ovulation to the same extent in rats. Nutr Research 2010;30:731-738

Kalupahana NS, Claycombe K, Newman SJ, Stewart T, Siriwardhana N, Matthan N, Lichtenstein AH, Moustaid-Moussa N. Eicosapentaenoic Acid Prevents and Reverses Insulin Resistance in High-Fat Diet-Induced Obese Mice via Modulation of Adipose Tissue Inflammation. J Nutr. 2010;140(11):1915-1922.

Rockett BD, Salameh M, Carraway K, Morrison K, Shaikh SR. n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo. J Lip Res. 2010;51, 1284-1297.

Shaikh SR, LoCascio DS, Soni SP, Wassall SR, Stillwell W. Oleic- and docosahexaenoic acid-containing phosphatidylethanolamines differentially phase separate from sphingomyelin Biochemica et Biophyscia Acta  Biomembranes. 2009;1788, 2421-2426.

Lora KR, Lewis NM, Eskridge KM, Stanek-Krogstrand K, Ritter-Gooder P. Validity and reliability of an omega-3 fatty acid food frequency questionnaire for first-generation Midwestern Latinas. Nutr Research 2010;30:550-557.

Whelan J, Jahns L, Kavanagh-Prochaska K. DHA: Measurements in Food and Dietary Exposure. Prostaglandins Leukot Essent Fatty Acids. 2009;81:133-136.

11/30/2011

" Broughton KS, Bayes J, Culver B. High alpha-linolenic acid and fish oil ingestion promotes ovulation to the same extent in rats. Nutr Res. 2010 Oct;30:731-8.
" Coleman RA, Mashek DG. Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling. Chem Rev. 2011 Oct 12;111:6359-86.
" Communicating the Health Benefits of Eating Fish: Framing the Message About Seafood, Newark, Delaware, September 20, 2011.
" Communicating the Health Benefits of Eating Fish. Fish for Health Conference, University of Florida, Tallahassee, July 27, 2011.
" Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V, Yan QW, Miyoshi H, Mashek DG. The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest. 2011 Jun 1;121:2102-10.
" Harris, M. Seafood should be next up on FDA plate. The Hill, February 1, 2011.
" Harris, M., Omega-3 Deficiency (O3D) in Pregnancy. Ten Years of Science from the 2001 FDA Advisory to the 2010 Dietary Guidelines. Society for Maternal Fetal Medicine, San Francisco, CA, February 11, 2011.
" Harris, M., Omega-3 Docosahexaenoic Acid (DHA): A Powerhouse Nutrient for Pregnancy, University of Colorado Denver, Department of Pediatrics, Denver, CO, January 25, 2011
" Hess T, Rexford J, Schauermann N, Harris M, Trinette R, Engle T and Mulligan C. Effects of two different dietary sources of long chain omega-3 highly unsaturated fatty acids on incorporation into the plasma, red blood cell, and muscle cell in horses (E-2011-4384) in revision Journal of Animal Science, September 2011.
" Hsueh, H.W., Zhou, Z., Whelan, J., Allen, K.G.D., Moustaid-Moussa, N., Kim, H. and Claycombe, K.J. 2011. Stearidonic and Eicosapentaenoic Acids Inhibit Interleukin-6 (IL-6) Expression in 1 Mouse Adipose Stem Cells via Toll-like Receptor-2 (TLR2) Mediated Pathway. J Nutr 141:1260-1266.
" Jin D, Guo H, Bu SY, Zhang Y, Hannaford J, Mashek DG, Chen X. Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure. Faseb J. 2011 Feb;25:754-64.
" Kalupahana NS, Claycombe K, Newman SJ, Stewart T, Siriwardhana N, Matthan N, Lichtenstein AH, Moustaid-Moussa N. Eicosapentaenoic Acid Prevents and Reverses Insulin Resistance in High-Fat Diet-Induced Obese Mice via Modulation of Adipose Tissue Inflammation. J Nutr. 2010;140(11):1915-1922.
" Nalin Siriwardhana, Nishan S Kalupahana, Sarah Fletcher, Wenting Xin, Kate J Claycombe, Ling Zhao, Arnold M Saxton, Annie Quignard-Boulange, and Naima Moustaid-Moussa, N-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines, in part via NF-kB dependent mechanisms, Accepted, J Nutritional Biochem, August 2011.
" Rett, B.S. and Whelan, J. 2011. Increasing Dietary Linoleic Acid Does Not Increase Tissue Arachidonic Acid Content in Adults Consuming Western-Type Diets: a Systematic Review. Nutr Metabol 8:36 (in press).
" Ong KT, Mashek MT, Bu SY, Greenberg AS, Mashek DG. Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning. Hepatology. 2011 Jan;53:116-26.
" Witkin SS, Skupski D, Herway C, Rudge MV, Saito F, Harris M. Fatty acid composition of mid-trimester amniotic fluid in women of different ethnicities. J Matern Fetal Neonatal Med. 2011 Aug 1.
" Weldon, K.A. and Whelan, J. 2011. Allometric Scaling of Dietary Linoleic Acid on Changes in Tissue Arachidonic Acid using Human Equivalent Diets in Mice. Nutr Metabol 8:43 (in press).
" Whelan, J., Gouffon, J. and Zhao, Y. 2011. Effects of dietary stearidonic acid on biomarkers of lipid metabolism. J Nutr (in press, 2011).

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