SAES-422 Multistate Research Activity Accomplishments Report

Sections

Basic Information
Additional Info

Status: Approved

Basic Information

Project No. and Title: NC_old1170 : Advanced Technologies for the Genetic Improvement of Poultry
Period Covered: 01/03/2022 to 01/15/2024
Date of Report: 03/20/2023
Annual Meeting Dates: 01/14/2023 to 01/15/2023

Sue Lamont Adnan Alrubaye Doug Rhoads Eric Wong Huaijun Zhou Wayne Kuenzel Brynn Voy Fiona McCarthy Giri Athrey Yvonne Dreschler Nisha Pillai Darrell Kapzynski Wes Warren Behnam Abasht Samuel Aggrey Jiuzhou Song Tom Porter Gale Strasburg Kent Reed Bindu Nanduri Hans Cheng

Brief Summary of Minutes of Annual Meeting

NIFA rep Angilca Van Goor National Program Leader in the division of Animal System, 2^nd level rep. Frank was unable to come due to a flight cancellation
- No notes from Frank to relate to this group.
- The new AFRI RFA was supposed to be released last month. It was held up in the chain of command. The RFA will be released in 2 months.
- The next RFA will be for 2 years and they expect it to be for 2 years moving forward. The RFA will be released in the next 2 months, and it will have information for 2023 and 2024.
- AFRI got an increase of $10 million dollars for a total of $455 million. We expect flat funding.
- The dual purpose dual benefit is only applicable to large animals.
Sue Lamont report:
- Quick assessment: Great project productivity; thank you to Brynn. Timeline, experimental station directors are reviewing the proposal expect minor revisions. revisions are due June 01^st; expect approval by mid-July. Look for that information in mid-July.
- We have lost 11 members compared to last cycle. Some members were inactive, changed from 37 to 26.
- The experimental station director will help. We need to encourage scientists to apply and become members. We welcome relevant members who are not members in experimental stations. Send the experimental station leader an email and let them know that there is a new NC1170 project and that you want to join.
- Local units may have funding, and some may have no funding If you are a member, some experimental stations may direct some multistate money to members.
- Election of next secretary for NC1170: Chair Adnan, Secretary: Yvonne selected.
- Kent Reed NRSP8: the project meeting is this afternoon. Plan is to have another NRSP8 meeting in PAG. One of the major changes is that it won’t be the same project. The organizational structure will focus on the three aims. More in the meeting this afternoon. NRSP8 funding available for junior scientists and students.
- Voting on NC1170 meeting location. Meeting next year will be at PaG over the weekend.

Accomplishments

Dr. Lamont collaboration with Drs. Zhou, UC-Davis; Abasht and C. Schmidt from the U Delaware resulted in the identification of genomic regions associated with response of indigenous African chickens to Newcastle disease virus.
Zhou collaboration with ADOL and ISU, H.H. Cheng, H. Cheng, J. Dekkers, M. Delany, C. Ernst, J. Fulton, S.J. Lamont, Cooperating scientists: R. Gallardo, T. Kelly, A. Muhairwa, P. Msoffe, B. Kayang, A. Naazie. S. Aggrey, R. Hawken, R. Okimoto, L. Fang, N. Yang, X. Hu resulted in identifying genetic variants associated with economically important traits in chickens and can be used to genetically improve productivity and poultry health.
Fiona McCarthy, University of Arizona; and Dr. Wesley Warren, University of Missouri research collaboration resulted in the characterization and annotation of immune cells and immunoglobulin-like receptors in the chicken genome that contribute to disease resistance.
Collaborative work between Dr. Malheiros of the North Carolina State University and his multistate partners resulted in four projects.
Dr. Strasburg of the Michigan Station collaborated with Dr. Kent Reed of the Minnesota station and Dr. Sandra Velleman from Ohio State University.

Impacts

The work of NC1170 explores fundamental biological mechanisms using the most advanced technologies available that contribute new knowledge for application to improve the poultry industry's genetics, breeding, and production. The main impact includes: The next generation of scientists were trained in contemporary genomic technologies in the context of the project’s research, collaborative projects with industry facilitated the translation of research findings into application, and the results of the project were disseminated at a workshop at an international scientific conference.
Identified genetic variants associated with economically important traits in chickens and can be used to genetically improve productivity and poultry health.
is Identification of genomic regions associated with response of indigenous African chickens to Newcastle disease virus.
Characterization and annotation of immune cells and immunoglobulin-like receptors in the chicken genome that contribute to disease resistance.
Understanding role of early heat or cold stress on gene expression in the turkey hatchling from slow-growing and modern commercial turkey lines. We investigated the effects of exposure of satellite cells, which are progenitors of muscle cells in the turkey hatchling, to hot or cold temperatures.

Publications

Walugembe, M., Naazie, A., Mushi, J.S., Akwoviah, G.A., Mollel, E., Mang'enya, J.A., Wang, Y., Chouicha, N., Kelly, T., Msoffe, P.L.M. Otsyina, H.R., Gallardo, R.A., Lamont, S., Muhairwa, A.P., Kayang, B.B., Zhou, H., Dekkers, J.C.M. 2022. Genetic analyses of response of local Ghanaian and Tanzanian chicken ecotypes to a natural challenge with velogenic Newcastle disease virus. Animals 12:2755. doi.org/10.3390/ani12202755

Guan D, Halstead MM, Islas-Trejo AD, Goszczynski DE, Cheng HH, Ross PJ, Zhou H. Prediction of transcript isoforms in 19 chicken tissues by Oxford Nanopore long-read sequencing. Front Genet. 2022 doi: 10.3389/fgene.2022.997460.

Botchway ,P.K., Amuzu-Aweh, E.N., Naazie, A., Aning, G. K., Otsyina, H.R., Saelao, P., Wang, Y., Zhou, H., Walugembe, M., Dekkers, J., Lamont, S.J., Gallardo, R.A., Kelly, T.R., Bunn, D. and Kayang, B.B. 2022. Host response to successive challenges with lentogenic and velogenic Newcastle disease virus in local chickens of Ghana. Poultry Science 101:102138. doi.org/10.1016/j.psj.2022.102138.

Tudeka, C.K., Aning, G.K., Naazie, A., Botchway, P.K., Amuzu-Aweh, E.N., Agbenyegah, G.K., Enyetornye, B., Fiadzomor, D., Saelao, P., Wang, Y., Kelly, T.R., Gallardo, R., Dekkers, J.C.M., Lamont, S.J., Zhou, H., and Kayang, B.B. 2022. Response of three local chicken ecotypes of Ghana to lentogenic and velogenic Newcastle disease virus challenge. Tropical Animal Health and Production 54:134. doi.org/10.1007/s11250-022-03124-8

Lake, J.A., Yan, Y., Dekkers, J.C., Qiu, J., Brannick, E.M. and Abasht, B., 2022. Identification of circulating metabolites associated with wooden breast and white striping. PloS one, 17(9), p.e0274208. https://doi.org/10.1371/journal.pone.0274208

Smith, J. M. Alfieri, N. Anthony, P. Arensburger, G. N. Athrey, J. Balacco, et al.: “Fourth Report on chicken genes and chromosomes.” Cytogenet Genome Res. 2023. DOI: 10.1159/000529376.

Christina L. Swaggerty, Ramon D. Malheiros, Ludovic Lahaye, Hector Hernandes Salgado, J. Allen Byrd II, Kenneth J. Genovese, Haiqi He, Elizabeth Santin, Michael H. Kogut. Addition of a protected complex of biofactors and antioxidants to breeder hen diets confers transgenerational protection against Salmonella enterica serovar Enteritidis in progeny chicks. Poultry Science (accepted, in press).

Carvalho, L.C., Malheiros, D.,Lima, M.B., Mani, T.S.A., Pavanini, J.A., Malheiros, R.D., Silva, E.P. Determination of the Optimal Dietary Amino Acid Ratio Based on Egg Quality for Japanese Quail Breeder, Agriculture, 13, 173.

Malheiros, R.D., V. M. B. Moraes, K. E. Anderson, F. L. S. Castro, and J. E. Ferrel. Influence of dietary dacitic tuff breccia on laying hen performance and egg quality parameters and bone structure at 85 weeks of age after a non-anorexic molt program at 73 to 77 weeks. 2022, Poultry Science 101:101718.

Reed KM, Mendoza KM, Xu J, Strasburg GM, Velleman SG. Transcriptome Response of Differentiating Muscle Satellite Cells to Thermal Challenge in Commercial Turkey. Genes (Basel). 2022 Oct 14;13(10):1857. doi: 10.3390/genes13101857. PMID: 36292741

Reed KM, Mendoza KM, Strasburg GM, Velleman SG. Transcriptome response of proliferating muscle satellite cells to thermal challenge in commercial turkey. Frontiers in Physiology. 2022. Aug 25;13:970243. doi: 10.3389/fphys.2022.970243. PMID: 36091406

Xu J, Strasburg GM, Reed KM, Velleman SG. Thermal stress and selection for growth affect myogenic satellite cell lipid accumulation and adipogenic gene expression through mechanistic target of rapamycin pathway. Journal of Animal Science. 2022 Aug 1;100(8):skac001. doi: 10.1093/jas/skac001. PMID: 35908789.

Xu J, Strasburg GM, Reed KM, Velleman SG. Temperature and Growth Selection Effects on Proliferation, Differentiation, and Adipogenic Potential of Turkey Myogenic Satellite Cells Through Frizzled-7-Mediated Wnt Planar Cell Polarity Pathway. Frontiers in Physiology. 2022. May 23;13:892887. doi: 10.3389/fphys.2022.892887. PMID: 35677087

Xu J, Strasburg GM, Reed KM, Velleman SG. Thermal stress affects proliferation and differentiation of turkey satellite cells through the mTOR/S6K pathway in a growth-dependent manner. PLoS One. 2022 Jan 13;17(1):e0262576. doi: 10.1371/journal.pone.0262576. PMID: 35025965.

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