Brief Summary of Minutes of Annual Meeting

Brief summary of minutes of annual meeting (October 4-5, 2018):

Thursday, October 4, 2018

8:30-9:00am -    Opening remarks: Mike Harrington, WAAES Director, exiting W4122 Admin. Advisor, provided updates on WAAES and USDA budgets, funding priorities and initiatives. Emphasized importance of carefully crafted activities reports, particularly outcomes and impacts. Introduced Dr. Cris Pristos, NVAES Director and incoming W4122 Admin. Advisor, who provided additional updates and insights on successful practices of the NVAES multistate groups. 

9:00am-5:30pm - State Reports/project updates: (30-45 min Presentations/discussion): 

9:00 am                Bill Helferich – University of Illinois; Health risks and chemistry of abused fry oils

9:30 am                David Williams – Oregon State University; Analysis and impact of very low dose benzopyrenes from diet

10:00 am             Break

10:30 am             Nancy Turner – Michigan State University; Bioactive dietary components that impact colon health.

11:00 am             Tiffany Weir – Colorado State University; Benefits of cricket consumption as an alternative protein source; Interaction of gut microbiome and cardiometabolic health

12:00 pm             Lunch break

1:30 pm               Efren Delgado – New Mexico State University; Detection of food pathogens in food products

2:00 pm               Kaustav Majumder – University of Nebraska–Lincoln; Effect bioactive peptides on cardiovascular risk.

2:30 pm               Pratibha Nerurkar – University of Hawaii; Benefit of native Hawaiian fruits on diabetes risk.

3:00 pm               Break

3:30 pm               Chi Chen – University of Minnesota; Influence of food preparation on lipid peroxidation products and metabolites

4:00 pm               Adam Chicco – Colorado State University; Links between maternal obesity fetal metabolic programing.

6:00 pm               Group dinner – Culinary Institute of America, St. Helena, CA

Friday October 5, 2018:

9:00-10:30am; Business meeting at Calistoga Roastery coffee shop. Covered financial and budgetary information (Mike Harrington and Cris Pristos); Discussed format of final activities report, importance of clear and informative impact statements; Established plans for new collaborations; Voted to hold 2019 Annual Meeting in Estes Park, Colorado the third week of September, hosted by Tiffany Weir and Adam Chicco (Colorado State University), directed by David Williams (Oregon State).

Objective 1: Examine the effects of phytochemicals and other dietary components on gut microbiota and intestinal function.

W4122 scientists in Michgan demonstrated beneficial changes in the colon microbiota of rats when was included in the diet. These studies indicate that consuming a dried plum puree can enhance protection against intestinal disease, and that the benefit is partly derived through their effects on colonic microbiota and metabolic byproducts.

W4122 researchers in Colorado have determined that cricket consumption, which is growing in popularity as a sustainable and nutrition al food source, has prebiotic and anti-inflammatory effects in humans.

W4122 researchers in Colorado are establishing mechanistic links between gut microbiota and intestinal function and early predictors of cardiovascular disease risk that may lead to novel therapeutic approaches for heart disease prevention.

W4122 researchers in Michigan have demonstrated that diets containing certain polyphenolic compounds (derived from dried plums) impact the microbiota and their metabolism, which has significant impacts on multiple pathways involved in inflammation and tumorigenesis involved in the development of colorectal cancers.

Objective 2: Identify cellular mechanisms and host molecular targets of beneficial or adverse dietary components that influence human health.

In collaboration with Lawrence Livermore National Laboratory and Pacific Northwest National Laboratory, W4122 researchers in Oregon performed the first pharmacokinetic analysis of benzo[a]pyrene (a polycyclic aromatic hydrocarbon, (PAH)) in humans following oral exposure and the impact of food containing high levels of multiple PAHs.

With the application of molecular fluorescence spectroscopy for in situ, real-time detection of foodborne pathogens, W4122 scientists in New Mexico are revolutionizing the way we can detect of food pathogens in food products in tissues, thereby helping to better meet food safety requirements in agricultural and industrial food production.

W4122 researchers Wisconsin have begun to identify the mechanisms underlying the regulation of dietary iron absorption by IRP1 and HIF2alpha. By elucidating new ways in which dietary iron absorption is controlled it may be possible to develop the means to more safely combat the anemia in production animals and humans as illustrated by our planned experiment using dietary fumarate as a possible means to enhance intestinal HIF2alpha level.

W4122 researchers in Wisconsin are identifying how dietary iron absorption and red cell production are controlled which may be of use in humans (anemia of prematurity) or swine (iron deficiency associated with growth) where control (increase) of iron absorption from the diet may ameliorate disease.

W4122 researchers in Hawaii have discovered that noni juices, specifically the commercial noni juices, may not be equipotent to ameliorate the development of diabetes suggested by some studies, possibly due the differences in the composition of their bioactive components. Since most of the commercial noni products have not been tested for their beneficial properties in humans, this is an area worth investigating further.

W4122 researchers in Colorado have discovered that maternal high-fat feeding alters fetal metabolism in a manner that might predispose offspring to the development of diabetes in late childhood. Teams are using an ovine model to investigate the role of placental fatty acid transport in mediating this response, perhaps leading to novel therapies or dietary interventions that can protect the fetus from a potentially harmful environment during development.

W4122 researchers in Colorado have developed new methodology for non-invasive monitoring of metabolism in individual oocytes and embryos, which can predict how well they will develop using assisted reproduction technologies in both humans and animals (e.g., horses and cattle).

W4122 researchers from Utah identified candidate miRNAs in the GSTA cluster associated with the observed GST silencing that may underlie the susceptibility phenotype in DT. After a 10-day dietary treatment of AFB1 (300 ppb) in groups of Eastern Wild and Broad Breasted White (DT) turkeys, we obtained livers from 10 animals in each group, also including control birds from both types. Using our turkey liver miRNA-seq dataset, we identified 163 precursor miRNAs with high sequence similarity (BLAST e-score <1e-20) to miRNAs known from other organisms and 13 potentially novel turkey precursor miRNAs that are not similar to known miRNAs but that are also not embedded in annotated repeat sequences or coding sequences, and are not similar to snoRNA, mtRNA, tRNA or other types of RNA. These 176 precursor miRNAs correspond to 256 mature miRNAs expressed at biologically relevant levels and six of the top ten most highly expressed miRNAs are also among the top 10 in chicken liver.

Objective 3: Explore the interaction between dietary components and the host metabolome and epigenome.

W4122 researchers in Colorado have identified metabolomic signatures associated with high and low fruit and vegetable intake that may be more precise in predicting intake of these foods than the currently used self-report methods.

Objective 4: Determine how food processing influences chemical composition to affect human health.

W4122 researchers in Illinois found that thermally abused fying oil (TAFO) results in greater invasion and progression of cancerous cells injected into the leg bones of mice. Breast cancer metastasizes to bone in the majority of patients with advanced disease. the effects of thermally abused frying oil on metastasis of BC cells from bone to visceral tissue were investigated.

Other activities and achievements:

W4122 scientists organized a session on “protein and bio-functions” in the annual meeting of American oil chemist society in 2019.

W4122 researchers in New Mexico managed the Southwest Agriculture and Food Security Education project, which graduated students participating in research activities, financed Summer internships with USDA or the food industry for master students in the master’s program, and increased students’ retention rate through direct mentoring.

Milestones/Plans for 2019: Dr. Eisenstein will conclude a developmental study in mice to understand how dietary iron absorption and erythropoiesis are controlled by IRP1.

Dr. Turner will be continuing her project to explore the impact of baking on the chemopreventive capacity of sorghum, and the impact of diet on radiation-induced changes in apoptosis. We will be initiating our study of inflammation and tumor development in response to diets containing dried plum. We will also be initiating an experiment to determine if the protection conferred by sorghum at the early stages of colon cancer results in fewer tumors.

Dr. Majumder will develop clinically applicable dietary-peptide-based therapeutics for the improved treatment of hypertension and other cardiovascular diseases. We plan to continue to determine the impact of IRP1 in controlling dietary iron absorption in mice and to begin to determine if IRP1 control of HIF2alpha is important in the control of dietary iron absorption in neonatal swine.

Dr. Nerukar will be continuing her project to explore the impact of fNJ and cNJ on gut microbiome in our HFD-fed mice models. We will also investigate the metabolomics profiles of other functional foods such as bitter melon.

Dr, Williams recruited, enrolled and micro-dosed 5 volunteers with 4 doses (25, 50, 100 and 250 ng) of benzo[a]pyrene. The timeline given for the grant funding this project has a target of completing this study with 5 volunteers by November 30, 2019.

Dr. Helferich will continue to work on the development of models of breast cancer metastasis and will evaluate the potential of diet and diets containing thermally abused frying oil to modulate development of mammary tumor development.

Dr. Weir is exploring the role of cricket chitin in modulating the gut microbiota, particularly whether Bifidobacterium can selectively use chitin as a sole carbon source. Additionally, she plans to do in vivo assays to look at direct effects of chitin and cricket powder on inflammation and barrier function in intestinal epithelial cells.

Dr. Weir is also conducting a translational study to look at whether microbiota from humans with vascular dysfunction can recapitulate this phenotype in gnotobiotic animals. Additionally, she will exploring the relation between microbiota and vascular function in a human population.

Dr, Weir will apply machine learning and bioinformatics approaches to existing metabolomic dataset to generate preliminary data and establish optimal biofluids/metabolomic platforms for quantifying F&V intake.

Dr. Chicco will optimize and apply new methodology for studying oocyte and embryo metabolism in vitro to determine effects of maternal omega-3 fatty acids on embryo health and development. 

Dr. Coulombe plans to investigate the functional relevance of candidate miRNAs that could influence human susceptibility to cancer from food components by transfecting turkey hepatocytes with anti-anti miRNAs.

Grants awarded or ongoing (18 new or continuing research grants totaling over $10M to study effects of bioactive nutrients on cancer, diabetes, fetal programming by maternal diet, gut health, and cardiovascular risk).

NASA. PI: Nancy Turner with Robb Chapkin. Radiation-induced apoptosis avoidance and colon tumorigenesis: Epigenetic regulation in adult stem cells. $888,218 direct/$1,267,846 total costs. Funded 1/7/16 – 1/6/20. NNX15AD64G.

USCP. PI: Nancy Turner. Colon cancer chemoprevention with sorghum – impact of cooking. $184,971 direct/total costs. Funded 6/1/15 – 12/31/19. RN001-15.

California Dried Plum Board. PI: Nancy Turner with Raymond Carroll. Chemoprotective effects of prunes on colon carcinogenesis. $415,000 direct/total costs. Funded 8/1/18-7/30/21. Grant 580-02.

NASA. Co-PI: Nancy Turner with John Lawler (PI) and John Ford. Attenuation of space radiation-induced pro-oxidant and fibrotic signaling in the heart by nutritional and genetic interventions: Adventures in tissue sharing. $104,272 direct/$150,000 total costs. Funded 7/1/17 – 6/30/19.

USDA. PI: Nancy Turner with Robb Chapkin, Guoyao Wu and Raymond Carroll. Polyphenol-rich sorghum brans promote colon health via microbial mechanisms. $350,017 direct/$499,999 total costs. Funded 5/15/18 – 5/14/21. 2018-67017-28149.

HATCH Supplement (Nerurkar: PI)    09/01/18 to 08/31/20; $80,000; Specialty Crops: From Farm to Human Health

OHSU/OSU Cancer Prevention and Control Initiative Pilot Projects- “Zebrafish as a Model for Chemoprevention of T-Cell Lymphoblastic Leukemia (T-ALL)”, $50,000, 1/1/16-12/31/17, Williams PI.

NIH, NIEHS, “Benzo[a]pyrene Micro-dosing of Humans: A New Tool for Exposure, Risk Assessment and Prevention”, R01 ES028600-01A1, 01-01-2018-11/30/2022, $2.51 million (total), Williams, PI, Tilton, co-I.

Zhu, M. J. (PI), Navarre, R., Chew, B. USDA-NIFA (2018-67017-27517). Pigmented potato restores gut epithelial health impaired by obesity. $500,000 (5/2018 – 5/2021)

Du, M., Zhu, M. J. (co-PI). NIH (R01HD067449). Maternal obesity, AMPK and fetal brown adipogenesis. $ 1,561,745 (8/2017-7/2022).

Du, A., Y. Lin, W.V. Bernie, and M. J. Zhu (co-PI). USDA-NIFA. Nanomaterials-enhanced multiplex immunosensing device for rapid and sensitive detection of pesticide residues. $500,000. (3/2018 – 2/2021).

Zhu, M. J. (PI), Navarre, R., Du, M. Pacific Northwest Potato Council. Pigmented potatoes modulate gut microbiota and improve gut health. $67,239. (9/2016 –8/2019).

Zhu, M. J. (PI). National Processed Raspberry Council. Dietary raspberry, gut microbiota and inflammatory bowel disease. $108,844. (10/2014 – 9/2018)

Zhu, M. J. (PI), Zhang, H., Chang, E. B. Emerging Research Issues Competitive Grant, WSU. Mechanisms beyond preventive effect of fruit consumption on colorectal cancer. $80,000 (5/2016 – 12/2018).

Chicco, PI. NIFA/AFRI Research Grant # 2015-67017-23143 “Elucidating the effects of dietary PUFAs on inflammation and cardiometabolic risk” Period: February 2015- February 2019; Total costs: $499,998

Chicco: PI; Colorado Agricultural Experimental Station (USDA); “Maternal nutrition and fetal metabolic programming: role of placental lipid handling”; Period: May 2017- April 2019; Total costs: $50,000

Chicco Co-PI; Advanced Industries Accelerator Grant (CO Office of Economic Development and International Trade); “A Multi-sensor micro-chamber platform for metabolic screening to improve the quality and efficiency of oocyte and embryo selection in ART clinics” Period: October 2017- September 2019; Total costs: $97,000

Chicco, PI; NIH/NICHD 1R21HD097601-01; “Integrative metabolism of oocyte development and its modulation by maternal diet”09/24/18-08/31/20; $150,000/yr

Publications:

45 new publication by W4122 members (bolded) in 2017-2018 addressing effects of bioactive nutrients on health and chronic disease risk, as well as basic insights into metabolism, development of new methodology and technologies.

Molero, L., Campos, L., Sosa, L., Mao, Y., Flores, N., Delgado, E., Lozano, K. 2018. Development and Characterization of Glandless Cottonseed Meal/Pullulan Fine Fiber Mats. Archives of Nanomedicine, Accepted for publication July 2018.

Cuj-Laines, R., Hernández-Santos, B., Reyes-Jaquez, D., Delgado, E., Juarez-Barrientos, J.M., Rodriguez-Miranda, J. 2018. Physicochemical properties of ready-to-eat extruded nixtamalized maize based snacks enriched with grasshopper. International Journal of Food Science & Technology. Accepted for publication. DOI:10.1111/ijfs.13774.

Kim, E., G.A. Wright, R.S. Zoh, B.S. Patil, G.K. Jayaprakasha, E.S. Callaway, I. Ivanov, N.D. Turner, R.S. Chapkin. 2018. Establishment of a multi-component dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model. European Journal of Cancer Prevention (In press).

Seidel, D.V., S.S. Taddeo, M.A. Azcarate-Peril, R.J. Carroll, and N.D. Turner. Dried plums protect against chemically-induced colon carcinogenesis in Sprague Dawley rats. Journal of Nutrition (Accepted with revision).

Nerurkar, P.V.*, Orias, D., Soares, N., Kumar, M. and Nerurkar, V.R. Momordica charantia (Bitter melon) modulates adipose inflammasome gene expression and adipose-gut inflammatory crosstalk in high-fat diet (HFD)-fed mice. J Nutritional Biochem, Submitted revisions Oct 2018

Housley, L, Magaana, A.A., Hsu, A., Beaver, L.M., Wong, C.P., Stevens, J.F., Choi, J., Jiang, Y., Bella, D., Williams, D.E., Maier, C.S., Shannon, J., Dashwood, R.H. and Ho, E. (2018). Untargeted Metabolic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts. Molec. Nutr. Fd. Res., Jan 28, 2018 [Epub ahead of print], PMID: 29377494.

Hummel, J.M., Madeen, E.P., Siddens, L.K., Uesugi, S.L., McQuistan, T., Anderson, K.A., Turteltaub, K.W., Ognibene, T.J., Bench, G., Krueger, S.K., Harris, S., Smith, J., Tilton, S.C., Baird, W.M. and Williams, D.E. (2018) Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in Humans: Impact of Co-Administration of Smoked Salmon and BaP Dietary Restriction. Fd. Chem. Toxicol. 115:136-147, PMID: 29518434.

Williams, D.E. (2018) Association is not Causation (letter). Toxicol. Sci. 164:3.,DOI: 10.1093/toxsci/kfy095.

Bibi, S., M. Du, and M. J. Zhu. 2018. Dietary red raspberries reduces colorectal inflammation and carcinogenic risk in DSS-induced colitis in mice. Journal of Nutrition, 148, 667-674.

Bibi, S., Y. Kang, M. Du, and M. J. Zhu. 2018. Dietary red raspberries attenuate dextran sulfate sodium-induced acute colitis. Journal of Nutritional Biochemistry, 51:40-46.

Sun, X., and M. J. Zhu. 2018. Butyrate inhibits indices of colorectal carcinogenesis via enhancing α-ketoglutarate-dependent DNA demethylation of mismatch repair genes. Molecular Nutrition Food Research, 62: 1700932.

Sun, X., M. Du, D. A. Navarre and M. J. Zhu. 2017. Purple potato extract promotes intestinal epithelial differentiation and barrier function by activating AMP-activated protein kinase. Molecular Nutrition and Food Research, 62(4):1700536.

Sun, X., Q. Y. Yang, C. J. Rogers, M. Du, and M. J. Zhu. 2017. AMPK regulate intestinal differentiation via histone modification of CDX2. Cell Death and Differentiation, 24: 819-831.

Sun, X., X. Fu, M. Du, and M. J. Zhu. 2018. Ex vivo gut culture for tracing gut epithelial development. Open Biology, 8: 170256.

Wang, B., F. Zhang, H. Zhang, Z. Wang, Y. Ma, M. J. Zhu, and M. Du. 2017. Alcohol intake aggravates adipose browning and muscle atrophy in cancer associated cachexia. Oncotarget, 8: 100411-100420.

Wang, B., Z. Wang, J. M. de Avila, M. J. Zhu, F. Zhang, N. A. Gomez, L. Zhao, Q. Tian, J. Zhao, J. Maricelli, H. Zhang, B. D. Rodgers, and M. Du. 2017. Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB Journal, 31:4612-4622.

Xing, T., Y. Kang, X. Xu, B. Wang, M. Du, and M. J. Zhu. 2018. Raspberry supplementation improves insulin signaling and promotes brown-like adipocyte development in white adipose tissue of obese mice. Molecular Nutrition and Food Research, 2018, 62:1701035.

Zhao, J., Q. Yang, L. Zhang, X. Liang, X. Sun, B. Wang, Y. Chen, M. J. Zhu, and M. Du. 2017. AMPKa1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Biochemical and Biophysical Research Communications, 491: 508-514.

Zhao, L., T. Zou, N. A. Gomez, B. Wang, M. J. Zhu, and M. Du. (2018). Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1. Nutrition & Diabetes, 8: 39.

Zhu, M. J., Kang, Y., Y. Xue, X. Liang, M. P. Gonzalez Carcia, D. Rodgers, D. K. Kagel, M. Du. 2018. Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice. Journal of Nutritional Biochemistry, 53:96-103

Zou, T., B. Wang, Q. Yang, J. M. de Avila, M. J. Zhu, J. You, D. Chen, and M. Du. 2018. Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) 1. Journal of Nutritional Biochemistry, 55:157-164.

Gentile CL and Weir TL. The gut microbiota at the intersection of diet and health. Science (in press)

Shah MS, DeSantis TZ, Yamal JM, Weir TL, Ryan EP, Cope JL, Hollister EB. Re-purposing 16S rRNA gene sequence data for within-case paired tumor, tumor-adjacent biopsy, and fecal samples to identify reproducible microbial markers for colorectal cancer. PLoS One (in press)

Soderborg TK, Mulligan CE, Clark SE. Babcock L, Janssen RC, Lemas DL, Johnson LK, Frank DN, Weir TL, Barbour LA, Hernandez TL, Kuhn KA, D’Alessandro A, El Kasim KC, Friedman JE (2018) The Gut Microbiota in Infants of Obese Mothers Increases Hepatic Inflammation and Susceptibility to Obesity and NAFLD in Germ-free Mice. Nature Communications (in press).

Stull VJ, Finer E, Bergmans RS, Febvre HP, Longhurst C, Manter DK, Patz J, Weir TL. (2018) Impact of Edible Cricket Consumption and Gut Microbiota in Healthy Adults, a Double-blind Crossover Trial. Scientific Reports. 8, 10762

Lee DM, Battson ML, Jarrell DK, Hou S, Ecton KE, Weir TL, Gentile CG. (2018) SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the intestinal microbiota in type II diabetic mice. Cardiovascular Diabetology, 17:62.

Gindin M, Febvre HP, Rao S, Wallace TC, Weir TL. (2018) Bacteriophage for Gastrointestinal Health (PHAGE) Study: Evaluating the Safety and Tolerability of Supplemental Bacteriophage Consumption. Journal of the American College of Nutrition. Doi: 10.1080/07315724.2018.1483783.

Battson ML, Lee DM, Weir TL, Gentile CG (2018) The gut microbiota as a novel regulator of cardiovascular function and disease. Journal of Nutritional Biochemistry 56: 1-15.

Salem G, Al-Feki W, Manter DK, Byrne P, Stromberger ME, Weir TL. (2018) Water stress tolerance of winter wheat (Triticum aestivum L.) genotypes are improved by ACC deaminase bacteria. Rhizosphere 8: 1-7.

Cox-York KC, Stoecker E, Hamm AK, Weir TL (2018) Microbial Metabolites in Cancer Promotion or Prevention. In: Microbiome and Cancer (ed. Robertson ES). Springer International Publishing, Cham, Switzerland.

Battson ML, Lee DM, Jarrell D, Hou S, Ecton K, Weir TL, Gentile CG (2017) Suppression of Gut Dysbiosis Reverses Western Diet-Induced Vascular Dysfunction. Am J Physiol- Endocrinol & Metabol doi: 10.1152/ajpendo.00187.2017.

Guha, S., Majumder, K. (2018). Structural-features of food-derived bioactive peptides with anti-inflammatory activity: A brief review. Journal of Food Biochemistry, DOI: 10.1111/jfbc.12531.

Li, Q., Kang, X., Shi, C., Li, Y., Majumder, K., Ninga, Z., Ren, Y. (2018). Moderation of hyperuricemia in rats via consuming walnut protein hydrolysate diet and identification of new antihyperuricemic peptides. Food & Function, 1: 107-116.

Chee, M., Majumder, K., Mine, Y. (2017). Intervention of dietary dipeptide gamma-L-glutamyl-L-valine (γ-EV) ameliorates inflammatory response in a mouse model of LPS-induced sepsis. Journal of Agricultural and Food Chemistry, 65: 5953–5960.

Majumder, K., Fukuda, T., Zhang, H., Sakurai, T., Taniguchi, Y., Watanabe, H., Mitsuzumi, H., Matsui, T., Mine, Y. (2017). Intervention of isomaltodextrin mitigates intestinal inflammation in a dextran sodium sulfate-induced mouse model of colitis via inhibition of toll-like receptor-4. Journal of Agricultural and Food Chemistry, 65: 810-817.

Fukuda, T., Majumder, K., Zhang, H., Matsui, T., Mine, Y. (2017). Adenine has an anti-inflammatory effect through the activation of adenine receptor signaling in mouse macrophage. Journal of Functional Foods, 28: 235-239.

Obeidat Y, Catandi GD, Carnevale EC, Chicco AJ, DeMann A, Field S, Chen T. A Multi-Sensor System for Measuring Bovine Embryo Metabolism Biosensors and Bioelectronics in press

Pennington ER, Sullivana EM, Fix A, Dadooc S, Zeczycki T, DeSantis A, Schlattner U, Chicco AJ, Brown DA, Shaik SR. Proteolipid domains form in biomimetic and cardiac mitochondrial vesicles and are regulated by cardiolipin concentration but not monolyso-cardiolipin. J Biol Chem in press, 2018.

Chicco AJ, Le CH, Gnaiger E, Dreyer HC, D’Alessandro A, Nemkov TG, Hocker AD, Prenni JE, Sindt N, Lovering AT, Subudhi AW, Roach RC. Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lesson from AltitudeOmics. J Biol Chem 293(18): 6659-6671, 2018. PMID: 29540485

Sloan DB, Warren JM, Williams AM, Wu Z, Abdel-Ghany SE, Chicco AJ, Havird JC. Cytonuclear integration and co-evolution. Nat Rev Genet., In press. PMID: 30018367

Chung DJ, Sparanga, GC, Chicco AJ, Schulte PM. Patterns of mitochondrial membrane remodeling parallel functional adaptations to thermal stress. J Exp Biol, 221:jeb174458, 2018. PMID:29643174

Chung DJ, Healy TM, McKenzie JL, Chicco AJ, Sparagna GC, Schulte PM. Mitochondria, temperature, and the pace of life. Integr Comp Biol. 2018 Apr 30. doi: 10.1093/icb/icy013. In press. PMID: 29718252

Obeidat Y, Evans AJ, Tedjo W, Chicco AJ, Carnevale EM , and Chen T Monitoring of Oocyte/Embryo Respiration Using Electrochemical-Based Oxygen Sensors. Sensors and Actuators B: Chemical, 276 (10):72-81, 2018.

Reed, K.M., Mendoza, K.M. Abrahante, J., and Coulombe, R.A. (2017). Response of the Hepatic Transcriptomes of Domesticated and Wild Turkey to Aflatoxin B1. Presented at the Annual Conference of the International Society of Animal Genetics, Dublin, IR. July 2017.

Reed, K.M., Mendoza, K.M., Abrahnte, Juan and Coulombe, R.A. (2018) Comparative Response of the Hepatic transcriptomes of Domesticated and Wild Turkey to Aflatoxin B1. Toxins 10 (1) 1-24. doi:10.3390/toxins10010042