• Basic Information
• Additional Info

Basic Information

• Project No. and Title: NE1201 : Mycobacterial Diseases of Animals
• Period Covered: 01/01/2016 to 12/31/2016
• Date of Report: 12/30/2016
• Annual Meeting Dates: 12/04/2016 to 12/04/2016

Participants

Bannantine, John - USDA-ARS Barletta, Raul - University of Nebraska–Lincoln Bermudez, Luiz - Oregon State University Coussens, Paul - Michigan State University DeKuiper, Justin - Michigan State University Frie, Meredith - Michigan State University Grohn, Yrjo - Cornell Holland, Margo - NIFA-USDA Johnson, Peter - NIFA-USDA Kapur, Vivek - Pennsylvania State University Mohamed, Asmaa - Michigan State University Olson, Ken - KEO Consulting Quinn, Fred - University of Georgia Rathnaiah, Govardhan - University of Nebraska–Lincoln Smith, Becky - University of Illinois at Urbana-Champaign Sporer, Kelly - Michigan State University Talaat, Adel - University of Wisconsin Wells, Scott - University of Minnesota

Accomplishments

Impacts

1. Research on the evaluation of prevention of infection by stimulating innate response using Mycobacterium bovis as the model of infection.
2. Establishment of model systems that can be used to obtain crucial information that would unveil key aspects of MAP pathogenesis, and would enable the researchers to compare the different phases of the disease between in vitro and in vivo systems.
3. Determining the role of luxR homolog gene in invasion of MAP into epithelial cells using Mycobacterium smegmatis as a model of infection.
4. Investigation of the phenotypic diversity in the immune response against Mycobacterium avium subsp. paratuberculosis in MAP-infected dairy cows.
5. Identification of several candidate MAP proteins of potential utility for the early detection of MAP infection.
6. Detection of pathogens and control pathogen transmission, both within-herd transmission and between-herd transmission.
7. Development of a quantitative methodology for incorporating whole genome sequence (WGS) data into bacterial transmission models for infectious diseases incorporating ecology, economics, molecular biology, and epidemiology.
8. Better understanding of the principles and dynamics governing transmission of mycobacterial infection.
9. Development, assessment, and implementation of vaccines for JD and bTB.
10. Providing veterinarians, producers of potentially impacted species, state and federal policy makers, and other stakeholders with accurate, high quality, up to date, and easy to access information and education to assist efforts that will effectively address mycobacterial diseases.

Publications