SAES-422 Multistate Research Activity Accomplishments Report

Sections

Basic Information
Additional Info

Status: Approved

Basic Information

Project No. and Title: NE1201 : Mycobacterial Diseases of Animals
Period Covered: 12/01/2012 to 12/01/2013
Date of Report: 01/22/2014
Annual Meeting Dates: 10/19/2013 to 10/19/2013

Brief Summary of Minutes of Annual Meeting

Legacy attachment file:

[Minutes]

Dr. Grohn leads the epidemiology research group, as they concentrate on the study design of clinical trial of vaccine and the assessment of vaccination effectiveness in farm animal populations against endemic infectious diseases. His research group has also designed a 3-step framework of a Bayesian modeling and simulation approach, and the model was experimented in a simulated case study for a killed whole-cell vaccine against paratuberculosis in dairy herds. Dr. Grohn was able to estimate key model parameters from the longitudinal prevalence data of the whole herd (adult animals) and the control and vaccinated groups in a vaccinated herd. Extension is led by Dr. Ken Olson, as they continue to collaborate with the VBJDCP to address education, share information, and provide tools for producers, other scientists, industry partners, and USDA. Dr. Olson also attends DC meetings with USDA leadership (APHIS, NIFA, ARS,), partner organizations (AVMA, IDFA, NMPF, NASDA, AFBF), and Congressional staff. Furthermore, his efforts concentrate on the awareness of the MDA MI among stakeholders, industry and government leaders. Dr. John Bannatine leads the diagnosis research group as they continue to research on the newly identified MAP specific monoclonal antibody, 17A2 that can for the first time differentiate MAP from other Mycobacterium. JDIP Vaccine development led by Dr. Murray Hines has reached its final stage, and publications are in the process. The data from the vaccine study will be published in the Frontiers in Microbiology Journal.

Impacts

Application of an established mathematical model of infection in data collection from the longitudinal study done in three states (NY, PA, VT) for approximately 10 years.
Implementation of a faster test-and-removal plan with a 2-month testing interval in epidemic disease control of the bTB in cattle herds.
Establishment of a Bayesian computation (ABC with an efficient sequential Monte Carlo method) modeling and simulation approach to estimate the effectiveness of vaccination against infectious diseases in food animal populations.
Evaluation of vaccine efficacy and development of standard evaluation in the validation of vaccine candidates.
Comparison and evaluation of the fully sequenced two USA virulent M. bovis isolates.
Establishment of a sample repository from JDIP samples for further testing and evaluation.
Evaluation of vaccine candidates against MAP in controlled blinded studies.

Publications

The attached meeting minutes contain a listing of the 13 posters presented at the morning and afternoon poster sessions. Please refer to that attachment for details.

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