SAES-422 Multistate Research Activity Accomplishments Report

Status: Approved

Basic Information

Participants

Audrey Adler (Rutgers U), Jennifer Anderson (Colorado State University), Jay Whelan (U of Tennessee), S Raza Shaikh (East Carolina University), Shane Broughton (U of Wyoming), Jennifer Yen (Western Kentucky University), Kimberly Heidal (ECU), Deb Palmer (Rutgers U), Deepika Bangia (Rutgers U), Concetta Di Russo (U of Nebraska - Lincoln), Nancy Lewis (UN Lincoln), Cami Wells (UN Lincoln), Doug Mashek (U of Minnesota), Mary Harris (CSU), Susan Welsh (USDA - NIFA), Elena Serrano (Virginia Tech)

Annual Meeting NC-1039 October 7th - 9th, 2009

N-3 Polyunsaturated Fatty Acid and Human Health and Disease

East Carolina University, Greenville, NC

Wednesday October 7th


Nutrition Education/eXtension: ABC's of n-3 content. To launch an eXtension website, we need 250

content pages and 100 FAQs. Deb received a grant from the Center for Advanced Food Technology to

pay Deepika to work on this for 3 years. As part of her degree, she will be evaluating the eXtension

website and helping to coordinate content for the eXtension site.

We have proposed to develop three communities of interest (CoI):

    1. Omega-3s for Prevalent Health Conditions. Some of these conditions including heart disease; asthma; arthritis; pregnancy; attention deficit disorder; and Alzheimer's disease - This CoI will include individuals with these and other conditions, their caregivers, and some healthcare providers.)

    2. Omega-3s for Health - This CoI includes Extension Specialists, County Agents, and the general public.

    3. Omega-3s for Higher Education Professional Training - This CoI includes university and college healthcare program educators and students, e.g., those from departments such as nutrition, medicine, nursing, etc.  This one will be developed last and in a year or two.


Breakout sessions: We created and compiled a list of FAQs and possible headings for content

pages and entered them into Excel. We also began writing the actual responses/pages.


Thursday October 8th


NIFA: Susan Welsh provided an update on CSREES (now NIFA) (handouts provided): NIFA

leadership, priorities, and grant mechanisms (NRI now AFRI); and eXtension.


Group Membership: We discussed membership. Invitations to join the project will be sent to:

Carol Lammi-Keefe, LSU clammi-keefe@agcenter.lsu.edu; Doris Hicks, U of Delaware


Officers for 2010-2011: Doug Mashek (Secretary), Elena Serrano (Chair).


eXtension:

Brief overview of what it will take for a successful eXtension site (for those not present on

Wednesday)


Assistance needed in the following:

  • Need help with Jennifer

  • Need someone to be in charge of FAQs - Cami

  • Someone in charge of ask the expert eventually - not until the website is launched. Mary Harris will take leadership of this.

  • Need web expert - Deepika will help input information and provide web support


Plan for further development of content

  • Establish ongoing writing/content groups

  • Working meetings: in-person and conference call schedule


Friday October 9th


Plan for further development of content and continue of writing


Future Meetings:

Monthly Video-Conference Calls: We will have a monthly video-conference call. Deb will send out an email about possible days/times and connect with the eXtension technical person to make sure the days/times work. Everyone will need to purchase a camera. Doug will follow-up about possible online services that we can use.

Next Annual Meeting: October 20 - 22, 2010, Washington, DC. Susan Welsh will block 12 rooms for the 19th and 20 until the 22nd. Thanks, Susan!

Community of Practice: We will meet in Colorado or Tennessee. Deb will follow-up with everyone about dates and include other people from the CoP. People will also meet at EB on Friday and Saturday on April 23 and 24th. Susan will see if she can book a room.


Accomplishments

Short-term Outcomes

Outputs

-Expansion of in vivo (experimental animals fed HED) data for n-3 forms and amounts for health promotion and disease prevention

-Establishing in virto (cell culture) models of n-3 PUFA effects

-In vitro effects of n-3 PUFA forms on biomarkers of health promotion and disease prevention

-Expansion of in vivo (experimental animals fed HED) data for n-3 forms and amounts for health promotion and disease prevention

-Increased database defining the health benefits of n-3 PUFA forms

-Data on n-3 PUFA intakes in diverse populations

-Expansion of food-based n-3 PUFA for optimal health and disease prevention

-Web material development for education and training of nutrition professionals

-Dissemination of data in peer-reviewed journals, scientific and professional meetings

-Expansion of in vivo (experimental animals fed HED) data for n-3 forms and amounts for health promotion and disease prevention


Milestones

(2008): Submission of a competitive grant application to USDA by one or more of the Station representatives

(2010): Symposium presentation of findings at national/international meetings, eg Experimental Biology meeting, International Society for the Study of Fatty Acids and Lipids (ISSFAL)

(2011): Symposium presentation of findings at national/international meetings, eg Experimental Biology, ISSFAL

(2012): Symposium presentation of findings at national/international meetings, eg Experimental Biology, ISSFAL, American Dietetic Association

(2012): Author a report directed at the governing organizations, such as USDA, IOM, and FDA

(2012): Redefinition of the DRI for n-3 PUFA at the conclusion of the project

Impacts

  1. Validation of the in vitro (cell culture) approach to defining n-3 Polyunsaturated Fatty Acid (PUFA) requirements, and defining its use as a high-throughput preclinical screening tool
  2. Establishing more definitive and form-specific Dietary Reference Intakes (DRIs) for n-3 Polyunsaturated Fatty Acids.
  3. Modification of the n-3 PUFA requirements to include forms other than alpha-Linolenic acid
  4. Decreased incidence and progression of degenerative and age-related diseases
  5. Education of the clients of nutrition professionals about the health benefits of n-3 PUFA
  6. Establishing a Community of Practice so that information from science can be made available through eXtension
  7. Education of the clients of nutrition professionals about the health benefits of n-3 PUFA
  8. Increased awareness by the medical community of the specific benefits of n-3 PUFA forms and amounts
  9. Validation of the in vivo experimental model for defining human equivalent doses in rodents for n-3 and n-6 PUFA
  10. Establishing more definitive and form-specific DRIs for n-3 PUFA
  11. Improved health of the U.S. population

Publications

Broughton KS, Hahn B, Ross E. Docosahexaenoic acid and eicosapentaenoic acid differently affect ovarian prostaglandin levels in rats. Nutrition Research 2009;29:510-518. Broughton KS, Rule DC, Ye Y, Zhang X,Driscoll M, Culver B. Dietary omega-3 fatty acids differentially influence ova release and ovarian COX-1 and COX-2 expression in rats. Nutrition Research 2009;29:197-205. Whelan, J., Jahns, L. and Kavanagh-Prochaska, K. DHA: Measurements in Food and Dietary Exposure. Prostaglandins Leukot Essent Fatty Acids. 2009;81:133-136. Harris, W.S., Lefevre, M., Dariush Mozaffarian, D., Toner, C., Colombo, J., Cunnane, S., Holden, J.M., Klurfeld, D.M., Morris, M.C. and Whelan, J. Towards Establishing Dietary Reference Intakes for Long Chain Omega-3 Fatty Acids. J. Nutr. 2009;139: 804S-819S. Liu LF, Koba K, Purushotham A, Wendel AA, Lee K, DeIuliis J, Belury MA. Regulation of adipose triglyceride lipase by rosiglitazone. Diab Obes Metab, 11(2):131-142, 2009 (ISI 2.434) Malinauskas, B. & Heidal, K. 2009. The relationship between physical activity, omega-3 fatty acids, and cardiovascular disease risk factors in college. Southeast Chapter of the American College of Sports Medicine. Sapiro JM, Mashek MT, Greenberg AS, Mashek DG. 2009 Hepatic triacylglycerol hydrolysis activates PPAR-±. Journal of Lipid Research 2009;50(8):1621-1629. Whelan, J. Dietary Stearidonic Acid is a Long Chain Omega-3 Polyunsaturated Fatty Acid with Potential Health Benefits. J. Nutr. 2009;139: 510. Whelan, J., Jahns, L. and Kavanagh-Prochaska, K. DHA: Measurements in Food and Dietary Exposure. Prostaglandins Leukot Essent Fatty Acids. 2009;81:133-136. Wortman, P., Miyazaki, Y., Kalupahana, N.S., Kim, S., Fletcher, S., Hansen-Petrik, M., Saxton, A., Claycombe, K.J., Voy, B.H., Whelan, J. and Moustaid-Moussa, N. Polyunsaturated Fatty Acids Modulate Prostaglandin E2 Secretion and Markers of Lipogenesis in Adipocytes. Nutr Metab 2009;21:5-27. Dvorak NJ, Riley RT, Harris M and McGregor JA. Fumonisin mycotoxin contamination of corn-based foods consumed by potentially pregnant women in Southern California. J Reprod Medicine 2008;53:672-676. Hansen, R.A., Harris, M.A., Pluhar, G.E., Motta, T., Brevard, S., Ogilvie, G.K., Fettman, M.J. and Allen, K.G.D. Fish oil decreases matrix metalloproteinases in knee synovia of dogs with inflammatory joint disease. J. Nutr. Biochem., 2008;19:101-108. McDaniel JC, Belury M, Ahijevych K, Blakely W. Omega-3 fatty acids effect on wound healing. Wound Repair and Regeneration 2008;16:337-345 (ISI 1.700) McEntee, M.F., Ziegler, C.C., Reel, D.,Tomer, K., Shoieb, A., Ray, M., Li, X., Nielsen, N., O'Rourke, D. and Whelan, J. Dietary Polyunsaturated Fatty Acids Modulate the Response of Androgen-Dependent Prostate Cancer to Hormone Ablation and Progression to Androgen-Independent Growth. Am J Pathol. 2008;173:229-41. Whelan, J. Health Implications of Changing Linoleic Acid Intakes. Prostaglandins Leukot Essent Fatty Acids 2008;79:165-167. Whelan, J. (n-6) and (n-3) Polyunsaturated Fatty Acids and the Aging Brain: Food for Thought. J. Nutr. 2008:138: 2521-2522.
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